Genetic Testing for AMD

Genetic Testing for AMD -Research Review| February 2011

A 75 year old white mail recently presented to the office with bilateral drusen and mild retinal pigment epithelium (RPE) changes, but no opbvious hemorrhage or fluid. HIs vision still measured 20/25 O.U., and optical coherence tomography revealed just small modulation within the RPE that was associated with the drusen.

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Prediction Model for Prevalence and Incidence of Advanced Age-Related Macular Degeneration Based on Genetic, Demographic, and Environmental Variables | February 2011

PURPOSE:The joint effects of genetic, ocular, and environmental variables were evaluated and predictive models for prevalence and incidence of AMD were assessed.

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Genetic Advancements in AMD:
A Glimpse at the Future -page 18| November 2010

Anti-VEGF therapy is the current standard of care for the treatment of wet AMD. But, even as remarkable as anti-VEGF treatment is, there are some drawbacks. Fortunately, current and ongoing genetic research has helped us to better understand the intricate disease processes associated with dry AMD development. In the very near future, these findings may ultimately lead to the production of several cutting-edge pharmaceutical agents that specifically target the genes responsible for macular degeneration.

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A genetic approach to stratification of risk for age-related macular degeneration | January 2010

Age-related macular degeneration (AMD) is the leading cause of blindness in Canada, affecting primarily older individuals. Aging of the ‘baby boomers’’ is expected to more than double the number of Canadians 65 years of age or older to just over 9 million in 2031. This trend is also expected to double the number of Canadians with AMD from the population affected currently: 1 million with early AMD, 250 000 with advanced AMD, and 64 200 with blindness due to AMD.y.

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