Meso-Zeaxanthin Studies

Targeting AMD with a Critical Carotenoid | March 2011

The role of nutrition, including carotenoid intake is receiving increasing attention for its potential in preventing age-related macular degeneration. This article will explore the science behind mesozeaxanthin, one of the macular carotenoids that is showing remarkable potential. Exciting new research at the University of Utah Medical School reveals that the protective effect of the combination of meso-zeanthin (MZ) with lutien and zeanthin is more potent than any of these carotenoidsindividually.

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Resolution of macular drusen following supplementation with mesozeaxanthin | 

Age-related macular degeneration (AMD) is the leading cause of blind registration in people over 50 years of age in the developed world. Late AMD results in loss of central and colour vision, with consequential difficulty in performing fine-detail visual tasks such as reading, driving, and recognizing faces, therefore impacting greatly on one+s independence and quality of life. It is estimated that late AMD affects more than 1.75 million individuals in the United States, and this figure is expected to rise to almost 3 million by 2020.1

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Augmentation of Macular Pigment Following Supplementation with All Three Macular
Carotenoids: An Exploratory Study | 2010

PURPOSE: At the macula, the carotenoids meso-zeaxanthin (MZ), lutein (L), and zeaxanthin (Z) are
collectively referred to as macular pigment (MP). This study was designed to measure serum and
macular responses to a macular carotenoid formulation.

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Studies on the singlet oxygen scavenging mechanism of human macular pigment | October 2010

Macular pigment (MP) was first described as a ‘‘yellow spot” centered on the fovea of the human eye in the 18th century, and it was classified spectroscopically as a xanthophyll carotenoid by Wald in 1945 [1], but it was not until 1985 that Bone and Landrum chemically identified that the macular pigment is a mixture of the carotenoids lutein and zeaxanthin [2]. Macular pigment is diffusely found in the peripheral retina, but it is highly concentrated (100- fold) in the foveal region of the macula, often exceeding a peak value of 1 mM in many humans [3–7]. In addition to spatial specificity, there is also remarkable chemical specificity of uptake into the human macula. Despite over a dozen readily detectable carotenoids found in human serum, only lutein, zeaxanthin, and their metabolites are found in the retina. In the fovea, the ratio of (3R,30R,60R)-lutein to (3R,30R)-zeaxanthin to (3R,30S-meso)-zeaxanthin is 1:1:1, while in the peripheral retina, lutein predominates over the zeaxanthins by a 3:1:0 ratio [1,6,8].

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Antioxidant potential of meso-zeaxanthin a semi synthetic carotenoid | August 2009

Semi synthetic carotenoid meso-zeaxanthin was evaluated for its antioxidant potential in vitro and in vivo. Mesozeaxanthin was found to scavenge superoxide radicals, hydroxyl radicals and inhibited in vitro lipid peroxidation. Concentrations needed for 50% inhibition (IC50) were 27.0, 3.5 and 3.2 μg/ml, respectively. It scavenged 2,2-azobis- 3-ethylbenzthiozoline-6-sulphonic acid and 2,2-diphenyl-1-picryl hydrazyl radicals and IC50 were 46.5, 6.25 μg/ml, respectively. It also scavenged nitric oxide radicals and IC50 was found to be 2.2 μg/ml. Oral administration of mesozeaxanthin inhibited superoxide radicals generated in macrophages by 25.2%, 50.1% and 67.2% at doses of 50, 100 and 250 mg/kg b.wt., respectively. One month oral administration of meso-zeaxanthin to mice significantly increased catalase, superoxide dismutase, glutathione and glutathione reductase levels in blood and liver. Levels of glutathione peroxidase and glutathione-S-transferase were also found to be increased in the liver, in a dose dependent manner. These results showed that meso-zeaxanthin has significant antioxidant activity in vitro and in vivo.

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Macular pigment response to a supplement containing meso-zeaxanthin, lutein and zeaxanthin | May 2007

BACKGROUND: Age-related macular degeneration (AMD) is a disease with multiple risk factors, many of which appear to involve oxidative stress. Macular pigment, with its antioxidant and lightscreening properties, is thought to be protective against AMD. A result has been the appearance of dietary supplements containing the macular carotenoids, lutein and zeaxanthin. More recently, a supplement has been marketed containing, in addition, the third major carotenoid of the macular pigment, meso-zeaxanthin. The purpose of the study was to determine the effectiveness of such a supplement in raising macular pigment density in human subjects.

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Meso-zeaxanthin: a cutting-edge carotenoid | June 2004

Current evidence demonstrates that the carotenoids lutein, zeaxanthin and mesozeaxanthin are readily bioavailable and if supplemented will effectively increase macular pigment levels. The distinction between each remains a focus of research in many labs. John T Landrum, PhD, and Richard A Bone, PhD, investigate

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