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Supplementation with all three macular carotenoids: response, stability and safety | October 2011
The macula houses a yellow pigment, attributable to the carotenoids meso-zeaxanthin (MZ), lutein (L), and zeaxanthin (Z). Indeed, this pigment lends its name to the macula lutea (Latin for yellow), and is more recently referred to as macular pigment (MP).1 Interestingly, of the over 700 carotenoids identified in nature, these three dietary carotenoids selectively accumulate at the macula,1-3 indicating an exquisite degree of biological selectivity in this retinal tissue.
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Targeting AMD with a Critical Carotenoid | March 2011
The role of nutrition, including carotenoid intake is receiving increasing attention for its potential in preventing age-related macular degeneration. This article will explore the science behind mesozeaxanthin, one of the macular carotenoids that is showing remarkable potential. Exciting new research at the University of Utah Medical School reveals that the protective effect of the combination of meso-zeanthin (MZ) with lutien and zeanthin is more potent than any of these carotenoidsindividually.
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A genetic approach to stratification of risk for age-related macular degeneration Article | November 2010
Age-related macular degeneration (AMD) is the leading cause of blindness in Canada, affecting primarily older individuals. Aging of the ‘‘baby boomers’’ is expected to more than double the number of Canadians 65 years of age or older to just over 9 million in 2031.
Purpose: The genetic determinants of age-related macular degeneration (AMD) are reviewed and a novel approach to risk determination based upon inherited genetic polymorphisms and smoking history is presented. Although AMD was long thought to have primarily an environmental etiology, genetic variation is now known to account for the majority of the disease risk, with variations in the genes of the complement pathways playing a prominent role.
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Nutrition and Metabolism | November 2010
Macular pigment response to a supplement containing meso-zeaxanthin, lutein and zeaxanthi
Purpose: To determine the effectiveness of such a supplement in raising macular pigment density in human subjects.
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Archives of Biochemistry and Biophysics Article | November 2010
Studies on the singlet oxygen scavenging mechanism of human macular pigment
Purpose: In nature, carotenoids account for the red, orange, and yellow colors of fruits and vegetables, as well as animal skin and other external features. The role of carotenoids in photosynthesis has been extensively investigated, showing that their two major functions are light harvesting and photoprotection. Their potential function as stabilizers of biological membrane structure has also been reported
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Print of Current Eye Research Article | April 2010
Augmentation of Macular Pigment Following Supplementation with All Three Macular Carotenoids:An Exploratory Study
Purpose: At the macula, the carotenoids meso-zeaxanthin (MZ), lutein (L), and zeaxanthin (Z) are collectively referred to as macular pigment (MP). This study was designed to measure serum and macular responses to a macular carotenoid formulation.
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Study
Meso-zeaxanthin Ocular Supplementation Trial in Normals (MOST N)
Purpose: The centre of the macula has a distinct yellow colour attributable to the presence of a yellow pigment known as macular pigment (MP). MP is made up of the three lipid-like carotenoids meso-zeaxanthin (MZ), lutein (L) and zeaxanthin (Z) (ratio at the macula: 1: 1: 1).1; 2
The MOST N (ISRCTN60816411) study was designed to investigate, in adouble-blind, randomized placebo controlled fashion, changes in MP optical density (MPOD), and serum concentrations of the macular carotenoids in response to a supplement containing MZ, L and Z , in normal subjects.
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Reproducible Measurement of Macular Light Article by Dr. Newsome
Reproducible Measurement of Macular Light Flash Recovery Time Using a Novel Device Can indicate the Presence and Worsening of Macular Diseases
Purpose: To determine the safety, sensitivity, and specificity of a novel flash photorecovery timing instrument with response verification in diferentiating normal from abnormal maculae, and in detecting worsening macular disease.
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A Breakthrough in AMD
Meso-Zeaxanthin (MZ) is the key carotenoid in the fight against AMD3.
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MZ Supplementation Increases MPOD
Macular pigment response to a supplement containing meso-zeaxanthin, lutein and zeaxanthin
Background Age: Related macular degeneration (AMD) is a disease with multiple risk factors, many of which appear to involve oxidative stress. Macular pigment, with its antioxidant and light-screening properties, is thought to be protective against AMD.
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C-6940 Article
Keeping your macula healthy: The role of Lutein, zeaxanthin, and meso-zeaxanthin
This is the first of a three-part series investigating the science behind lutein and zeaxanthin in relation to the retina. This first article will provide background information about carotenoids, explain how their structure relates to function within the retina, and describe specifically how lutein and zeaxanthin may be beneficial in the prevention of onset or progression of age-related macular disease.
